Rabifuse-DSR

Product Information

Rabifuse-DSR is a combination of DOMPERIDONE + RABEPRAZOLE . it is used to treat symptoms of acid reflux due to hyperacidity, stomach ulcer (Peptic ulcer disease), and Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour). Besides this, it is used short-term to treat gastroesophageal reflux disease (GERD) symptoms. GERD is a condition in which the sphincter (valve) located at the uppermost part of the stomach gets irritated and damaged due to excessive stomach acid production. As a result, the stomach acid and juice flow back into the food pipe, leading to stomach upset and heartburn. Heartburn is the post-effect of acid reflux with a burning-like feeling that rises from the stomach towards the neck.

DOMPERIDONE + RABEPRAZOLE contains two medicines, namely Rabeprazole and Domperidone. Rabeprazole is a proton pump inhibitor that helps reduce stomach acid by blocking the actions of an enzyme (H + /K + ATPase or gastric proton pump). This gastric proton pump lies in the cells of the stomach wall. It is responsible for releasing gastric acid secretion and damaging tissues in the food pipe, stomach, and duodenum (uppermost part of the small intestine). On the other hand, Domperidone is a prokinetic agent that increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).

It is better to take DOMPERIDONE + RABEPRAZOLE an hour before a meal or without a meal for its best results. DOMPERIDONE + RABEPRAZOLE should be swallowed whole with a glass of water. Do not chew, crush, or break it. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back, and your condition may worsen. An adult taking DOMPERIDONE + RABEPRAZOLE might have common side effects like headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and arthralgia (joint pain). In the case of children taking DOMPERIDONE + RABEPRAZOLE, they might report upper respiratory tract infections (URI), headache, fever, diarrhoea, vomiting, rash, and abdominal pain. These side effects are temporary and may resolve after some time; however, if this persists, contact the doctor.

You can increase the efficacy of DOMPERIDONE + RABEPRAZOLE by taking a small meal or snacks frequently. Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes). Tell your doctor if you have stomach or intestinal cancer, liver problems, are allergic to DOMPERIDONE + RABEPRAZOLE or will have an endoscopy in the future. Prolonged intake of DOMPERIDONE + RABEPRAZOLE may cause a deficiency of Vitamin B-12 and low levels of calcium, magnesium, and Vitamin D, leading to osteoporosis (brittle or weak bones).

Uses of DOMPERIDONE + RABEPRAZOLE

Treatment of Gastro-Esophagal Reflux Disease (GERD), Acid reflux, Heartburn, Peptic ulcer, stomach ulcers, and Dyspepsia (stomach discomfort due to indigestion).

Medicinal Benefits

DOMPERIDONE + RABEPRAZOLE helps in reducing the excess amount of stomach. In turn, it prevents the formation of an ulcer in the upper part of the intestine (duodenal ulcer), gastro-esophagal reflux disease (GERD) with or without ulcer and Zollinger-Ellison Syndrome, in which the stomach makes exceptionally high amounts of acid. Besides, the DOMPERIDONE + RABEPRAZOLE also treats symptoms of nausea and vomiting in adults and children over 12 years of age (with at least 35 kg or more).

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of DOMPERIDONE + RABEPRAZOLE
  • Rash
  • Brittle bones
  • Low vitamin B-12
  • Loss of libido (sexual desire)
  • Cough
  • Sore throat
  • Runny nose
  • Flatulence (gas formation)
  • Back pain
  • Weakness or loss of strength
  • Sleeplessness
  • Headache
  • Dizziness
  • Benign polyps in the stomach
In-Depth Precautions and Warning
Drug Warnings

You should avoid taking DOMPERIDONE + RABEPRAZOLE if you are allergic to DOMPERIDONE + RABEPRAZOLE or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, are pregnant or planning for pregnancy, and breastfeeding mothers. DOMPERIDONE + RABEPRAZOLE may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of DOMPERIDONE + RABEPRAZOLE may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its tissues), Vitamin B-12, and magnesium deficiency. Intake of DOMPERIDONE + RABEPRAZOLE may mask the symptom of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool), immediately consult the doctor. Tell your doctor that you are using before having a specific blood test known as Chromogranin A.

Drug Interactions

Drug-Drug Interactions: DOMPERIDONE + RABEPRAZOLE may interact with a blood thinner (clopidogrel, warfarin), antifungal (ketoconazole, voriconazole, itraconazole, fluconazole, posaconazole), anti-HIV drug (atazanavir, amprenavir, nelfinavir), antacid (magnesium hydroxide, aluminium hydroxide, cimetidine), iron supplements, antibiotics (clarithromycin, erythromycin, ampicillin, rifampicin), heart medicine (atropine, digoxin, amiodarone), blood pressure-lowering medicines (diltiazem), anti-cancer drug (methotrexate) and anti-nausea pills (aprepitant).

Drug-Food Interactions: DOMPERIDONE + RABEPRAZOLE interacts with St John's wort plant that is used as an anti-depressant. This plant may affect the working of DOMPERIDONE + RABEPRAZOLE. So avoid its intake with DOMPERIDONE + RABEPRAZOLE.

Drug-Disease Interactions: DOMPERIDONE + RABEPRAZOLE should not be given in patients with C. difficile-induced colitis, liver disease, bone fractures, low Vitamin B12 (anaemia), and low magnesium (hypomagnesemia).

Drug-Drug Interactions Checker List:
  • LOPIDOGREL
  • WARFARIN
  • KETOCONAZOLE
  • VORICONAZOLE
  • ITRACONAZOLE
  • FLUCONAZOLE
  • ATAZANAVIR
  • AMPRENAVIR
  • NELFINAVIR
  • MAGNESIUM + ALUMINIUM HYDROXIDE
  • CIMETIDINE
  • IRON
  • ERYTHROMYCIN
  • RIFAMPICIN
  • ATROPINE
  • DIGOXIN
  • AMIODARONE
  • DILTIAZEM
  • METHOTREXATE
  • CLARITHROMYCIN
 
     
4017 Times Visited